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Within the next decade, Anabaptists emerged in Bohemia, southern Germany, and the Netherlands. Known as Mennonites after their Dutch leader Menno Simons d , Anabaptists have divided numerous times over issues related to both lifestyle and theology. Theological issues have entailed modes of baptism, the exercise of the ban or shunning , and interpretations of eschatology. Historically, music has also been a defining feature of Mennonite denominational separations, with a focus on tensions between traditional and contemporary repertoire, selection of hymnals, the use of musical instruments, the style of musical leadership, congregational song versus choral performance in worship, historic versus inclusive-language hymn texts, and philosophies of musical education You do not currently have access to this article.
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We correlate chromosome 5 haplotypes and SMN2 copy number with disease expression in 42 Mennonite and 14 Amish patients with spinal muscular atrophy SMA. No infant with 2 copies of SMN2 sat unassisted. All are alive at a median age of 11 range 2—31 years without ventilatory support. These phenotypic differences were not explained by variation in SMN1 deletion size or SMN2 coding sequence, which were conserved across haplotypes. Distinctive features of SMA within Plain communities provide a population-specific framework to study variations of disease expression and the impact of disease-modifying therapies administered early in life.
This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported in part by charitable financial contributions from the Amish and Mennonite communities served by the Clinic for Special Children.